A new drug combination Xylazine and Fentanyl has appeared. A gram of Fentanyl (1000 mg) will kill 500 people. Narcan (Naloxone) will not reverse Xylazine as it is not an opioid. Give the Narcan anyway because it will reverse the Fentanyl and may help to keep the person breathing till EMS arrives. Additional doses may be needed.